Document Type : Original Article
Authors
1
Department of Plant Protection, National Research Center Cairo. Egypt.
2
Department of Environmental Studies, Institute of Graduate Studies and Research. P.O. Box 832, Alerandria, 21526, Egypt
10.21608/jpces.2003.459403
Abstract
The existed residues of diazinon low concentration (DLC) in liver samples after 0, I, 3, 7, 15 and 21 days from dipping of rabbits were 0.05, 1.2, 3.8, 1.8, 0.87 and 0.0 ppm in kidney and 0.01, 0.9, 2.9, 1.5,0.31 and 0.0 ppm in liver, respectively. In case of dipping of rabbits in diazinon high concentration (DHC), the residues were elevated and the detected concentrations were 0.07, 4.5, 6.17, 4.62, 1.2 and 0.03 ppm in kidney samples after O, I, 3, 7, 15 and 21 days of exposure, respectively. Also the concentrations of diazinon residue in liver were 0.04, 3.01. 4.7, 3.85, 1.1 and 0.02 ppm, respectively, after the same pre-exposure periods. Effect of diazinon on aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine and urea were investigated in red Baladi rabbits. Seventy-two animals were distributed into three groups, the first dipped in tap water and served as control group. The second and the third groups were dipped in diazinon (0.6 and 3 mg / L water) and served as DLC and DHC, respectively for 10 sec. The previous step was repeated after 10 days. The animals were sacrificed by jugular vein incision after 0, I, 3, 7, 15 and 21 days following the second dipping of rabbits in diazinon. Both tested concentrations induced elevation of ALT, ALP and urea, while AST values were significantly (p<O.05) decreased. Also, a discernable change in creatinine levels. Meanwhile AST, ALT, ALP and urea were fluctuated during the time of treatment, however creatinine values were increased. The consistent correlation between the dizinon residues and the impairment of liver and kidney functions in rabbit's proof the possible alteration of animal physiology and its production.
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