1
Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University
2
Department of Histology, Faculty of Medicine, Alexandria University
10.21608/jpces.2001.459686
Abstract
Male CD-I nice (20 mice/group) were administered piperonyl butoxide in the diet at levels of0 (control), 0.1, 0.3, md 0.6% for 4 weeks (5 days/ week). Piperonyl butoxide induced essential hepatotoxicity, renal and brain toxicity with a dose-response relationship. Oedema and disturbance of hepatic architecture in liver, marked widening of interstitial spaces, ranked dilatation of renal tubules with flattened epithelium in kidneys, and patches of increased eosinophilia in the nuropls in brain were observed in the high termed group (0.6%) of piperonyl butoxide. These results indicated that pipronyl butoxide caused essential histological changes in liver, kidney, and brain of1Mle mice.
Farag, A., & Melies, A. (2001). Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs. Journal of Pest Control and Environmental Sciences, 9(1), 19-32. doi: 10.21608/jpces.2001.459686
MLA
Amina T. Farag; Anisa E. Melies. "Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs", Journal of Pest Control and Environmental Sciences, 9, 1, 2001, 19-32. doi: 10.21608/jpces.2001.459686
HARVARD
Farag, A., Melies, A. (2001). 'Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs', Journal of Pest Control and Environmental Sciences, 9(1), pp. 19-32. doi: 10.21608/jpces.2001.459686
VANCOUVER
Farag, A., Melies, A. Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs. Journal of Pest Control and Environmental Sciences, 2001; 9(1): 19-32. doi: 10.21608/jpces.2001.459686
)
