Comparative study on the toxic effect of short - term intraperitoneal administration of some insecticides on haematology and blood biochemistry parameters of male adult albino rats

The present study was conducted to investigate and compare the intoxication effects of daily interaperitoneal injection of 1/10 LD5dKg Body Wt. of Fenpropathrin, Dimethoate, Thiocyciam and Thionex for 5 days on complete blood picture and biochemical parameters of adult male albino rats. The daily intraperitoneal injection of any of the four insecticides for 5 days caused a significant increase in white blood cell count(WBC)which reach its maximal value of 101.7%, 85 6%, 63 9% and 9% compared to the control level.Fenpropathrin,Thiocyclam and Thionex showed a general decrease in red blood cell count (RBC), whereas Dimethoate produced significant increase in RBC count after two and five days of administration. The effect of Fenpropathrin, Thiocyclam and Thionex on hemoglbin content was parallel to their action on RBC count. Hematocrit value showed a general decrease in response to the tested insecticide except in Dimeothate insecticide, on the other hand, the mean corpuscular volume (MCV) was generally increased in Dimethoate, and hriocyclane insecticide compared whereas Fenpropathrin and Thionex produced a general decrease in MCV after two and five days of administration. Fenpropathrin, Dimethoate, Thiocyclam and Thionex produced a general decrease in mean corpuscular hemoglobin (MCH) after 2^nd and fifth days of administration. In addition, administration of Fenpropathrin, Dimethoate, Thiocyclam and Thionex caused, in general, decrease in mean corpuscular hemoglobin concentration (MCHC) during all the experimental periods. Finally, blood platelets count (PLT) showed general increase in response to Fenpropathrin, Dimethoate, Thiocyclam and Thionex administration. The daily intraperitoneal administration of any of the four insecticides for five days caused a general increase of urea and uric acid concentration in rat's blood serum compared to the control level. In general, creatinine concentration in rat's blood serum increased in response to the daily intraperitoneal injection of insecticides. Glucose content of rats blood serum showed different fluctuations in response to insecticides administration. In general, results indicated a general increase in serum cholesterol and triglycerides content at the different time intervals studied. It is possible to conclude that insecticides administration for 5 days, even at low doses i. e. 1/10 LD50/kg. Body wt., had harmful effects on blood, kidney and liver.