Document Type : Original Article
Authors
1
Department of Pesticide Chemistry and Faculty of Agriculture, Alexandria University
2
Department of Soil Fertility and Plant nutrition, Soil Water and Environment Research Institute (SWERI)
3
Central Laboratory for Food and Feed, Agriculture Research Center, Alexandria,
10.21608/jpces.2000.460512
Abstract
The present study was designed to investigate the effects of lead on maternal, paternal, and F I-generation iron, zinc, copper, and manganese levels in the liver, kidney, and brain Besides, lead residue levels were determined in the same tissues Male and female mice were exposed to 0 0026, 0 026, and 0 26% lead acetate (14 2 142, and 1420 ppm lead) via drinking water up to 70 days In addition, a cross-mating trial was conducted Analysis showed that the level of hepatic, renal, and brain lead was considerably reduced during pregnancy and lactation periods compared to that in nonpregnant state Also hepatic, renal, and brain lead was reduced in postmated males compared to premated males The changes of Cu, Zn, Mn, and Fe concentrations in tissues of premated male and female mice were similar to those induced by lead in postmated male and female mice during gestation and lactation periods No effects appeared on the concentrations of elements in Fl-female mice for the kidneys and brain compared to the control group and F1-female mice Residual lead was shown in the tissues of F1-female which produced from some combined groups, compared to the control The levels of lead residual significantly increased in the liver of female mice in some of combined groups compared to the control
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