Department of Biochemistry and Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
10.21608/jpces.1990.460679
Abstract
Rabbit brain monoamine oxidase (MAO) is rapidly inactivated when incubated with trans-Co(3-R-pyridine)4Cl2)Cl since R is methyl (CMPC) or ethyl (CEPC) group. These complexes inhibit MAO enzyme with time dependent and concentration dependent response with I50 value equal to 8.3x10-1 & 3x10-11 M respectively. 8.3x10-10 M from CMPC & CEPC inhibited the MAO enzyme by a noncompetitively inhibition type. The values of Km and Vmax were determined from the Lineweaver-Burk plot. The MAO enzyme is inhibited also by methyl pyridine which is a precursor of these complexes. This inhibition increased by increasing the concentration of methyl pyridine.
Shaban, N., & El-Subruiti, G. (1990). Inhibition of rabbit brain monoamine oxidase by trans-dichlorotetra (pyridine derivatives) of cobalt (iii) complexes.. Journal of Pest Control and Environmental Sciences, 2(1), 91-102. doi: 10.21608/jpces.1990.460679
MLA
Nadia Z. Shaban; Gehan M. El-Subruiti. "Inhibition of rabbit brain monoamine oxidase by trans-dichlorotetra (pyridine derivatives) of cobalt (iii) complexes.", Journal of Pest Control and Environmental Sciences, 2, 1, 1990, 91-102. doi: 10.21608/jpces.1990.460679
HARVARD
Shaban, N., El-Subruiti, G. (1990). 'Inhibition of rabbit brain monoamine oxidase by trans-dichlorotetra (pyridine derivatives) of cobalt (iii) complexes.', Journal of Pest Control and Environmental Sciences, 2(1), pp. 91-102. doi: 10.21608/jpces.1990.460679
VANCOUVER
Shaban, N., El-Subruiti, G. Inhibition of rabbit brain monoamine oxidase by trans-dichlorotetra (pyridine derivatives) of cobalt (iii) complexes.. Journal of Pest Control and Environmental Sciences, 1990; 2(1): 91-102. doi: 10.21608/jpces.1990.460679
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