1
Pesticide Dept., Fac. of Agric., Menofiya Univ., Egypt.
2
Genetics Dept., Fac. of Agric., Menofiya Univ., Egypt.
10.21608/jpces.1993.460817
Abstract
The genotoxic effect of systemic pesticide confidor was studied in male albino mice on gene expression (as key enzymes) such as alkaline phosphatase acetyl, cholinesterase, glutamic pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT) and total protein in blood serum. Confidor was given orally either as a single dose (1/4 LD50), sacrificing the animals 24, 48, and 69 hours post treatment, or as repeated dose using either 1/4 LD50 dose for four consecutive days or 1/10 LD50 for ten days. The calculated LD50 was 210 body weight. Serum albumin showed a gradual significant increase in quantity over 96 hr being higher in single dose treatment. Whereas globulin showed the opposite response. Confidor imposes a significant inhibitory effect on total protein biosynthesis, showing sever action at repeated doses as the time passed on. Aminotransferases enzymes (GPT and GOT) experienced biosynthesis inhibition under both scheme of treatment. Though there was a leveling up in GPT synthesis under repeated doses at 48 hr post treatment. In general cholinesterase and alkaline phosphatases.
El-Sheikh, A., Ammar, I., & Eissa, R. (1993). Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index. Journal of Pest Control and Environmental Sciences, 5(2), 75-89. doi: 10.21608/jpces.1993.460817
MLA
A. E. A. El-Sheikh; I. M. A. Ammar; Ragaa A. Eissa. "Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index", Journal of Pest Control and Environmental Sciences, 5, 2, 1993, 75-89. doi: 10.21608/jpces.1993.460817
HARVARD
El-Sheikh, A., Ammar, I., Eissa, R. (1993). 'Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index', Journal of Pest Control and Environmental Sciences, 5(2), pp. 75-89. doi: 10.21608/jpces.1993.460817
VANCOUVER
El-Sheikh, A., Ammar, I., Eissa, R. Genotoxicity of systemic pesticide confidor in male albino mice a- blood serum enzymes as an index. Journal of Pest Control and Environmental Sciences, 1993; 5(2): 75-89. doi: 10.21608/jpces.1993.460817
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